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[HTML] Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

[HTML] from nih.gov…, L Yang, TM Allen, AD Luster… - The Journal of clinical …, 2011 - ncbi.nlm.nih.gov
... Ivar Einarsson, 5 Linda Yang, 6 Todd M. Allen, 4 Andrew D. Luster, 3 Andrew ... Although
cholesterol-conjugated siRNAs silence gene expression without apparent toxicity in mucosal
epithelial cells and ... The lack of cellular toxicity of CD4-AsiCs might also make them an attractive ...
Cited by 3 - Related articles - All 8 versions

TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin

CH Lee, P Masso-Welch… - Journal of …, 2011 - Soc Leukocyte Biology
... To date, the most potent mucosal adjuvants belong to the family of bacterial HLTs, which is
comprised of two distinctive subfamilies [14–17]. ... LT-IIa-B5 purified in this manner fails to activate
TLR4-expressing cells, further confirming lack of biologically active endo- toxin [21]. ...

CK12, a rainbow trout chemokine with lymphocyte chemo-attractant capacity associated to mucosal tissues

J Montero, MC Ordas, A Alejo… - Molecular …, 2011 - Elsevier
... A further group of CX chemokines has been identified in zebrafish, which lack one of the two
N-terminus conserved cysteine residues but retain the ... Our studies revealed that this chemokine
is strongly expressed in mucosal tissues such as skin, gills or gut, and also by a specific ...
Related articles - All 2 versions

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R [gamma]-/-(NSG) BLT mice

CA Stoddart, E Maidji, SA Galkina, G Kosikova… - Virology, 2011 - Elsevier
... In our initial studies with NOD-scid mice, however, we observed poor reconstitution and
susceptibility to mucosal HIV challenge. ... We have not yet determined whether the lack of
B cells in cohort B was the result of using allogeneic CD34 + cells. ...
Cited by 1 - All 2 versions

Regulation and role of IL-7 in HIV-1 infection

[PDF] from ki.seHT Pham - year: 2011, 2011 - publications.ki.se
... Individuals who lack CCR5 expression on immune cells due to mutation in the CCR5 (Δ32) gene
are ... Depletion of CD4+ T cells happens not only in peripheral blood and GALT, but also at other
mucosal sites and in the lymph nodes. Studies in SIV and HIV-1 infection also ...
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