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A Member of the PLEIOTROPIC DRUG RESISTANCE Family of ATP Binding Cassette Transporters Is Required for the Formation of a Functional Cuticle in …

M Bessire, S Borel, G Fabre, L Carraça… - The Plant Cell …, 2011 - Am Soc Plant Biol
Although the multilayered structure of the plant cuticle was discovered many years ago, the molecular
basis of its formation and the functional relevance of the layers are not understood. Here, we
present the permeable cuticle1 (pec1) mutant of Arabidopsis thaliana, which displays ...
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The Role of ABC Transporters in Cancer Stem Cell Drug Resistance

VS Donnenberg, L Zimmerlin… - Cancer Stem Cells in …, 2011 - Springer
Abstract There can be no cure for epithelial cancer until there is a significant therapeutic index
that separates the most therapy-resistant cells within tumors, and the cells that mediate functions
essential to life. The cancer stem cell paradigm explains tumor heterogeneity and has led ...

[HTML] Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance

[HTML] from plos.orgSE Hensley, SR Das, JS Gibbs, AL Bailey… - PLoS One, 2011 - dx.plos.org
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV
chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human
isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody- ...
Cited by 5 - Related articles - Cached - All 5 versions

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

GJP Dijkgraaf, B Alicke, L Weinmann, T Januario… - Cancer research, 2011 - AACR
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a
common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently
under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC- ...
Cited by 4 - Related articles - All 4 versions

Multidrug-resistant tuberculosis: resistance rates to first and reserve antituberculosis drugs in the UK in 2008/9 and the role of rapid molecular tests for drug resistance

SL Mitchell, N Seoudi, DCS Hutchison… - Thorax, 2011 - thorax.bmj.com
Undiagnosed chronic obstructive pulmonary disease (COPD) is a major public health issue,
as it leads to patients missing out on appro- priate preventive and therapeutic inter-
ventions.1e3 The ratio of diagnosed/predicted COPD prevalence differs widely between ...
Cited by 1 - Related articles - All 3 versions

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