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Structural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)

G Kozlov, AY Denisov, M Girard, MJ Dicaire… - Journal of Biological …, 2011 - ASBMB
... The C terminus of the protein contains an HEPN (higher eukaryotes and prokaryotes
nucleotide-binding) domain of unknown function. Here, we determined the high-resolution
1.9-Å crystal structure of the HEPN domain from human sacsin. ...
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Eukaryote-to-eukaryote gene transfer gives rise to genome mosaicism in euglenids

[PDF] from biomedcentral.comS Maruyama, T Suzaki, A Weber… - BMC Evolutionary …, 2011 - biomedcentral.com
... symbiogenesis: ymbiogenesis: ymbiogenesis: euglenoid, uglenoid, uglenoid, dinoflagellate,
and inoflagellate, and inoflagellate, and sporozoan porozoan porozoan plastid origins and the
eukaryote ukaryote ukaryote family tree. J Eukaryot Microbiol 1999, 46(4):347-366. ...
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Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

AM Martelli, C Evangelisti, W Chappell, SL Abrams… - Leukemia, 2011 - nature.com
... The mTOR complex1 (mTORC1) regulates the assembly of the eukaryotic initiation
factor4F complex, which is critical for the translation of mRNAs that are important
for cell growth, prevention of apoptosis and transformation. ...
Cited by 1 - Related articles - All 3 versions

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

M Mollapour… - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
... Heat shock protein 90 (H sp90) is an essential e ukaryotic mol ecular c haperone that c arries
out these p rocesses in normal and cancer c ells. ... (1) The e xtent of Hsp90 p ost-translational modi
fications is greater in metazoans compared to single cell e ukaryotes, suggesting that ...

[HTML] Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

[HTML] from nih.govLS Steelman, WH Chappell, SL Abrams… - Aging (Albany …, 2011 - ncbi.nlm.nih.gov
... It regulates translation in response to nutrients and growth factors by phosphorylating components
of the protein synthesis machinery, including p70 S6K and eukaryoticinitiation factor
(eIF)-4Ebinding protein-1 (4EBP-1), the latter resulting in release of the eukaryotic initiation f ...
Cited by 4 - Related articles - All 5 versions

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