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PSEUDOMARKER: A Powerful Program for Joint Linkage and/or Linkage Disequilibrium Analysis on Mixtures of Singletons and Related Individuals

T Hiekkalinna, AA Schäffer, B Lambert… - Human …, 2011 - content.karger.com
A decade ago, there was widespread enthusiasm for the prospects of genome-wide association
studies to identify common variants related to common chronic diseases using samples of unrelated
individuals from populations. Although technological advancements allow us to query ...

Use of a Medical Records Linkage System to Enumerate a Dynamic Population Over Time: The Rochester Epidemiology Project

JL St Sauver, BR Grossardt, BP Yawn… - American Journal of …, 2011 - Oxford Univ Press
The Rochester Epidemiology Project (REP) is a unique research infrastructure in which the medical
records of virtually all persons residing in Olmsted County, Minnesota, for over 40 years have
been linked and archived. In the present article, the authors describe how the REP links ...
Cited by 2 - Related articles - All 4 versions

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13. 2

FA Wright, LJ Strug, VK Doshi, CW Commander… - Nature genetics, 2011 - nature.com
A combined genome-wide association and linkage study was used to identify loci causing variation
in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10
−8 ) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The ...
Cited by 1 - Related articles - All 4 versions

mapping complex disease genes using linkage disequilibrium and genome-wide association scans

LJ Palmer, NJ Timpson, DM Evans… - An Introduction to …, 2011 - books.google.com
FOUR mapping complex disease genes using linkage disequilibrium and genome- wide association
scans Lyle J. Palmer, Nicholas J. Timpson, David M. Evans, George Davey Smith, Lon R. Cardon
Summary Remarkable advances have occurred recently in our ability to detect genetic ...
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The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

KE Wickliffe, S Lorenz, DE Wemmer, J Kuriyan… - Cell, 2011 - Elsevier
Ubiquitin chains of different topologies trigger distinct functional consequences, including protein
degradation and reorganization of complexes. The assembly of most ubiquitin chains is promoted
by E2s, yet how these enzymes achieve linkage specificity is poorly understood. We have ...
Cited by 5 - Related articles - All 3 versions

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