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Single-neuron dynamics in human focal epilepsy

[PDF] from harvard.eduW Truccolo, JA Donoghue, LR Hochberg… - Nature …, 2011 - nature.com
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous
neuronal activity arising from unbalanced runaway excitation. Here we report the first examination
of spike train patterns in large ensembles of single neurons during seizures in persons ...
Cited by 3 - All 4 versions

[HTML] LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

[HTML] from plos.orgEH Seppälä, TS Jokinen, M Fukata, Y Fukata… - PLoS Genet, 2011 - dx.plos.org
Major remodeling of the neuronal synaptic network occurs during childhood. The quadrillion
synapses formed till the end of age two are trimmed to 500 trillion by age 10 through a selective
process of strengthening of ideal connections, removal of redundant ones, and formation ...
Cited by 1 - Cached

A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy

I Manna, A Gambardella, A Bianchi, P Striano… - Epilepsia, 2011 - Wiley Online Library
A splice site variation (c.603-91G>A or rs3812718) in the SCN1A gene has been claimed to
influence efficacy and dose requirements of carbamazepine and phenytoin. We investigated
the relationship between c.603-91G>A polymorphism and response to antiepileptic drugs ...
Related articles - All 3 versions

A population‐based study of long‐term outcomes of cryptogenic focal epilepsy in childhood: Cryptogenic epilepsy is probably not symptomatic epilepsy

EC Wirrell, BR Grossardt, EL So… - Epilepsia, 2011 - Wiley Online Library
Purpose: To compare long-term outcome in a popula- tion-based group of children with cryptogenic
versus symp- tomatic focal epilepsy diagnosed from 1980 to 2004 and to define the course of
epilepsy in the cryptogenic group. Methods: We identified all children residing in Olmsted ...
Related articles - All 4 versions

Seizure freedom following 49 years of refractory epilepsy due to focal cortical dysplasia

J Anderson, P Harder… - Journal of Neurology, …, 2011 - jnnp.bmj.com
Throughout most of his adult life, he received high doses of phenytoin (PHT 600 mg/day) and
carbamazepine (CBZ 1400–1600 mg/day) without seizure control from the sequential addition
of valproate, primidone, clonazepam, topiramate and lamotrigine at maximum tolerated ...
Cited by 1 - Related articles - All 5 versions

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