推荐同事 机构合作 中文 繁體中文 English 한국어 日本語 Português Español

美国ACCDON公司旗下品牌

021-33361733，021-33632861

chinasupport@letpub.com

登录 注册 新注册优惠

Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-β Production Independent of Cholesterol Efflux Activity

WS Kim, AF Hill, ML Fitzgerald… - … of Alzheimer's Disease, 2011 - IOS Press
Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer's disease. Aβ is derived
from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated
by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing ...

Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease

[PDF] from amazonaws.comRJ Suetani, B Sorrenson, JDA Tyndall… - Atherosclerosis, 2011 - Elsevier
Sequence alignments and modeling indicated residue R1068 to be located in an α-helix downstream
of the Walker B motif in the first nucleotide binding domain (NBD-1), in a position to form ionic
interactions with D1092 and E1093. Cholesterol efflux studies showed the efflux from TD ...

Transient Dyslipidemia Mimicking the Plasma Lipid Profile of Tangier Disease in a Diabetic Patient with Gram Negative Sepsis

C Palacio, I Alexandraki… - Annals of Clinical & …, 2011 - Assoc Clin Scientists
Tangier disease (familial alpha lipoprotein deficiency) is a rare genetic disorder of lipid metabolism
characterized principally by a severe deficiency of high density lipoprotein (HDL), accompanied
by low plasma levels of low density lipoprotein (LDL) cholesterol, normal or elevated ...

Association of HDL Deficiency with a Novel Mutation in the ABCA1 Gene

GU Denk, C Aslanidis, G Schmitz… - Experimental and …, 2011 - thieme-connect.com
... Key words. low HDL - hypoalphalipoproteinaemia - Tangier disease. ... Defects in the genes
encoding for apolipoprotein AI (apolipoprotein AI deficiency), LCAT (LCAT deficiency, fish eye
disease), and ABCA1 (Tangier disease) are well-understood causes for HDL deficiency. ...
Related articles - All 4 versions

High-Density Lipoprotein Metabolism

HB Brewer - Atlas of Atherosclerosis and Metabolic Syndrome, 2011 - Springer
... Structural defects in the apo AI gene complex, familial hypoalphalipoproteinemia, and Tangier
disease, as well as patients with elevated triglycerides, dense low-density lipoprotein and low
HDL, and the metabolic syndrome, have an increased risk of early heart disease. ...
Cited by 1 - Related articles - All 2 versions

联系我们 | 站点地图 | 友情链接 | 授权代理商 | 加入我们

© 2010-2024 中国: LetPub上海分公司    网站备案号：沪ICP备10217908号-1    沪公网安备号：31010402006960

增值电信业务经营许可证：沪B2-20211595

礼翰商务信息咨询（上海）有限公司      办公地址：上海市徐汇区漕溪北路88号圣爱大厦1803室

United States: Tel: 1-781-202-9968 Address: 400 5th Ave, Suite 530, Waltham, Massachusetts 02451