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Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10−/− Mice

EA Hopper-Borge, T Churchill, C Paulose… - Cancer research, 2011 - AACR
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as
multidrug resistance protein 7 (MRP7), is able to confer resistance to a variety of anticancer
agents, including taxanes. However, the in vivo functions of the pump have not been ...
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Quality Assessment and Correlation of Microsatellite Instability and Immunohistochemical Markers among Population-and Clinic-Based Colorectal Tumors:: Results …

…, S Gallinger, B Bapat, JL Hopper… - The Journal of Molecular …, 2011 - Elsevier
The detection of defective mismatch repair (MMR), as assessed by the presence of tumor microsatellite
instability (MSI) and/or loss of MMR protein expression by IHC, has been useful for risk
assessment, prognosis, and prediction of treatment in patients with colorectal cancer. We ...
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[HTML] Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

[HTML] from plos.org…, PN Baird, S Gallinger, P Newcomb, J Hopper… - PLoS Genetics, 2011 - dx.plos.org
Genome-wide association studies (GWAS) have identified several colorectal cancer (CRC) susceptibility
polymorphisms near genes that encode proteins in the bone morphogenetic protein (BMP)
pathway. However, most of the inherited susceptibility to CRC remains unexplained. We ...
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Does Palliative Care Have a Future in the Emergency Department? Discussions with Attending Emergency Physicians

CR Grudzen, LD Richardson, SS Hopper… - Journal of Pain and …, 2011 - Elsevier
Twenty emergency physicians participated (mean age 41 years, range 31–61 years, median
practice time nine years, 40% female). Providers acknowledged many benefits of palliative care
presence in the ED, including provision of a specialized skill set, time to discuss goals of ...

Fine-mapping of colorectal cancer susceptibility loci at 8q23. 3, 16q22. 1 and 19q13. 11: refinement of association signals and use of in silico analysis to suggest …

…, D Conti, P Newcomb, JL Hopper… - Human Molecular …, 2011 - Oxford Univ Press
We have previously identified several colorectal cancer (CRC)-associated polymorphisms using
genome-wide association (GWA) analysis. We sought to fine-map the location of the functional
variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and ...
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