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Hooked on benzodiazepines: GABAA receptor subtypes and addiction

KR Tan, U Rudolph… - Trends in neurosciences, 2011 - Elsevier
Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle
relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines
are often abused after chronic clinical treatment and also for recreational purposes. ...
Cited by 1 - Related articles - All 3 versions

Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology

TI Saari, M Uusi-Oukari, J Ahonen… - Pharmacological Reviews, 2011 - ASPET
GABA is the major inhibitory neurotransmitter in the central nervous system (CNS). The type
A GABA receptor (GABA A R) system is the primary pharmacological target for many drugs used
in clinical anesthesia. The α1, β2, and γ2 subunit-containing GABA A Rs located in the ...
Cited by 1 - Related articles - All 3 versions

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

U Rudolph… - Nature Reviews Drug Discovery, 2011 - nature.com
GABA A (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines — which
non-selectively target GABA A receptors containing the α1, α2, α3 or α5 subunits — have ...

A Comparison of the Safety of Olanzapine and Haloperidol in Combination with Benzodiazepines in Emergency Department Patients with Acute Agitation.

MP Wilson, K MacDonald, GM Vilke… - The Journal of …, 2011 - ncbi.nlm.nih.gov
BACKGROUND: Pharmacologic management of the agitated emergency department patient
is controversial. The combination of olanzapine + benzodiazepines is not recommended by the
manufacturer, but a recent report suggested harm only if the patient was intoxicated. ...
All 2 versions

Is there an association between the range of benzodiazepines available and the quality of prescribing?: An international comparison of Canada and Australia using …

S Kisely, A Smith, I Sketris… - … Meeting of the …, 2011 - espace.library.uq.edu.au
Kisely, Steve, Smith, Alesha, Sketris, Ingrid, Cooke, Charmaine, Gardner, David and Tett, Sue
(2008). Is there an association between the range of benzodiazepines available and the quality
of prescribing?: An international comparison of Canada and Australia using ...
Cached - All 2 versions

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