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VS Donnenberg, L Zimmerlin… - Cancer Stem Cells in …, 2011 - Springer
Abstract There can be no cure for epithelial cancer until there is a significant therapeutic index
that separates the most therapy-resistant cells within tumors, and the cells that mediate functions
essential to life. The cancer stem cell paradigm explains tumor heterogeneity and has led ...
[HTML] from plos.orgSE Hensley, SR Das, JS Gibbs, AL Bailey… - PLoS One, 2011 - dx.plos.org
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV
chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human
isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody- ...
Cited by 5 - Related articles - Cached - All 5 versions
L Parham, IL de Rivera, W Murillo… - AIDS research and …, 2011 - ncbi.nlm.nih.gov
Antiretroviral therapy has had a great impact on the prevention of mother to child transmission
(MTCT) of HIV-1. However, development of drug resistance, which could be subsequently transmitted
to the child, is a major concern. In Honduras and Belize the prevalence of drug resistance ...
GJP Dijkgraaf, B Alicke, L Weinmann, T Januario… - Cancer research, 2011 - AACR
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a
common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently
under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC- ...
Cited by 3 - Related articles - All 4 versions
SL Mitchell, N Seoudi, DCS Hutchison… - Thorax, 2011 - thorax.bmj.com
Undiagnosed chronic obstructive pulmonary disease (COPD) is a major public health issue,
as it leads to patients missing out on appro- priate preventive and therapeutic inter-
ventions.1e3 The ratio of diagnosed/predicted COPD prevalence differs widely between ...
Cited by 1 - Related articles - All 3 versions

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