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Biopharmaceutical characterization of some new papaverine decomposition products

A Czyrski, T Hermann, B Rubis, M Rybczynska… - Pharmazie, 2011 - Govi-Verlag
Papaverine hydrochloride is used as a spasmolytic agent in the treatment of acute renal colic
( Snir et al. 2008 ). It is an unstable drug and can be oxidized easily to papaverinol and papaveraldine
(Machovičová and Parrák 1955; Piotrowska 2006 ). Some time ago, the new derivatives ...
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Transient bilateral brainstem dysfunction caused by topical administration of papaverine

CM Moran, ME Mahla, B Reichwage, S Lewis… - Journal of …, 2011 - thejns.org
Papaverine has been associated with transient cranial nerve dysfunction after topical application
during craniotomy. The authors report similar dysfunction after the use of papaverine affected
brainstem structures. Two patients undergoing craniotomy for clipping of an aneurysm ...
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The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices

YT Hsu, G Liao, X Bi, T Oka, S Tamura… - Neuropharmacology, 2011 - Elsevier
The phosphodiesterase 10A (PDE10A) is highly expressed within dopaminoreceptive medium
spiny neurons (MSNs) of the striatum, which are implicated in various neurodegenerative diseases
and psychiatric disorders, such as Huntington's disease and schizophrenia. With its dual ...

New PDE4 inhibitors based on pharmacophoric similarity between Papaverine and Tofisopam

FJJ Bihel, H Justiniano, M Schmitt, M Hellal… - Bioorganic & Medicinal …, 2011 - Elsevier
Accepted Manuscript New PDE4 inhibitors based on pharmacophoric similarity between Papaverine
and Tofisopam Fr d ric JJ Bihel, H l ne Justiniano, Marti Schm tt, Malik Hellal, Mohamed A.
Ibrahim, Claire Lugnier, Jean-Jacqu s Bourguignon PII: S0960-894X(11)01121-8 DOI: ...

Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-[gamma] and IP3 receptors

K Itoh, T Ishima, J Kehler… - Brain research, 2011 - Elsevier
Papaverine, an inhibitor of phosphodiesterase (PDE) 10A, is gaining attention for its potential
in the treatment of neuropsychiatric diseases such as schizophrenia. However, the precise mechanisms
underlying the putative neuroprotective/neurotrophic actions of papaverine remain ...
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