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New Guidelines for Preventing Colchicine Drug Interactions

J Kelly - Arthritis Rheum, 2011 - medscape.com
August 31, 2011 — A new set of evidence-based guidelines provides an algorithm for reducing
colchicine doses to prevent toxicity in patients who are also taking drugs such as
cyclosporine, ketoconazole, ritonavir, clarithromycin, azithromycin, verapamil extended ...

Novel evidence‐based colchicine dose‐reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P‐glycoprotein …

RA Terkeltaub, DE Furst, JL DiGiacinto… - Arthritis & …, 2011 - Wiley Online Library
The ratios of the maximum concentration and area under the curve from time 0 to infinity for colchicine
plus CYP3A4/P-glycoprotein inhibitors versus colchicine alone were >125% across all
studies, with the exception of studies involving azithromycin. Significant DDIs were ...

Colchicine or Methotrexate, with Ursodiol, Are Effective After 20 Years in a Subset of Patients with Primary Biliary Cirrhosis.

J Leung, PA Bonis… - Clinical gastroenterology and …, 2011 - ncbi.nlm.nih.gov
BACKGROUND & AIMS: The combination of ursodeoxycholic acid (UDCA), colchicine, and methotrexate
(MTX) is effective therapy for a subset of patients with primary biliary cirrhosis (PBC) who do
not respond to UDCA. However, the durability of the response is unclear. We investigated ...
All 2 versions

… with Familial Mediterranean FeverPP39. Anti-TNF Therapy in Severe Uveitis of BEHÇET's Syndrome: Report of 27 PatientsPP40. Colchicine does not Decrease The …

K Yildirim, H Uzkeser, A Uyanik, S Karatay… - …, 2011 - Br Soc Rheumatology
Background: The aim of this study was to determine the alterations in serum copper (Cu), zinc
(Zn) and selenium (Se) levels in Familial Mediterranean Fever (FMF) patients as compared to
healthy controls. ... Methods: This study was conducted on 33 patients with FMF during ...

THE EFFECT OF MULTIPLE DOSE ATORVASTATIN ON THE SINGLE-DOSE PHARMACOKINETICS OF COLCHICINE ADMINISTERED TO HEALTHY ADULT …

MW Davis, S Wason… - Journal of the American …, 2011 - Am Coll Cardio Found
... Cardiol. Matthew W. Davis, Suman Wason, and Jennifer DiGiacinto DOSE UNDER FASTED
CONDITIONS ADMINISTERED TO HEALTHY ADULT SUBJECTS AS A SINGLE 0.6-MG
SINGLE-DOSE PHARMACOKINETICS OF COLCHICINE THE EFFECT OF MULTIPLE DOSE ...
All 2 versions

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