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[CITATION] The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking

A Radhakrishnan, LP Sun… - … of Organelle and Cell …, 2011 - Academic Press
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Role of Sterol Metabolite Lipids in Development

A Antebi - Annual Review of Biochemistry, 2011 - annualreviews.org
Sterol metabolites are critical signaling molecules that regulate metabolism, development, and
homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate
sterol-responsive nuclear hormone receptors to control these processes through feed- ...
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Suppression of the pancreatic duodenal homeodomain transcription factor-1 (PDX-1) promoter by sterol regulation element-binding protein-1c (SREBP-1c).

M Amemiya-Kudo, J Oka, Y Takeuchi… - Journal of Biological …, 2011 - ASBMB
Page 1. 1 Suppression of the pancreatic duodenal homeodomain transcription factor-1
(PDX-1) promoter by sterol regulation element-binding protein-1c (SREBP-1c) ... Abstract
Overexpression of sterol regulation element-binding protein-1c (SREBP-1c) in β ...
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The IDOL–UBE2D complex mediates sterol-dependent degradation of the LDL receptor

L Zhang, L Fairall, BT Goult, AC Calkin… - Genes & …, 2011 - genesdev.cshlp.org
We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL
receptor (LDLR). The molecular pathway underlying IDOL action, however, remains to be
determined. Here we report the identification and biochemical and structural ...
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Sterol Regulatory Element-Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor- …

T Karasawa, A Takahashi, R Saito… - … and Vascular Biology, 2011 - Am Heart Assoc
Methods and Results— Transgenic mice that overexpress SREBP-1c in the liver and
SREBP-1-deficient mice were crossed with low-density lipoprotein receptor (LDLR)–deficient
mice, and the plasma lipids and atherosclerosis were analyzed. Hepatic SREBP-1c ...
All 3 versions

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