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Development of t (8; 21) and RUNX1-RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple …

V Najfeld, N Wisch, J Mascarenhas, L Issa… - Cancer Genetics, 2011 - Elsevier
A 65-year-old patient with a high hemoglobin and hematocrit was treated for 14 months with
therapeutic phlebotomy when cytogenetics of bone marrow revealed 100% cells with the Ph
chromosome and 45% of the Ph+ cells contained trisomy 8. Treatment with tyrosine ...
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Chronic Myelogenous Leukemia

MJ Kluk… - Diagnostic Molecular Pathology in Practice, 2011 - Springer
The patient was a 50-year-old man with a history of hypertension and hyperlipidemia who presented
to his primary care physician for malaise, fatigue, and pain in the left upper quadrant. An enlarged
spleen was identified on physical exam and initial laboratory anal- ysis of the peripheral ...

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

[HTML] from hematologylibrary.orgEA Nelson, SR Walker, E Weisberg… - …, 2011 - bloodjournal.hematologylibrary.org
The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous
leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of
STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase ...
Cited by 3 - Related articles - All 4 versions

Efficient gene transfer with pseudotyped recombinant adeno-associated viral vectors into human chronic myelogenous leukemia cells

L Sellner, MR Veldwijk… - Leukemia & …, 2011 - informahealthcare.com
Gene transfer into chronic myelogenous leukemia (CML) cells may become of relevance for
overcoming therapy resistance. Single-stranded pseudotyped adeno-associated viruses of serotypes
2/1 to 2/6 (ssAAV2/1–ssAAV2/6) were screened on human CML cell lines and primary ...
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CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia

[PDF] from hematologylibrary.orgH Makishima, AM Jankowska… - …, 2011 - bloodjournal.hematologylibrary.org
Progression of chronic myelogenous leukemia (CML) to accelerated (AP) and blast phase
(BP) is because of secondary molecular events, as well as additional cytogenetic
abnormalities. On the basis of the detection of JAK2, CBL, CBLB, TET2, ASXL1, and ...
Cited by 3 - Related articles - All 3 versions

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