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The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A

[HTML] from hematologylibrary.orgMJ Flick, AK Chauhan, M Frederick… - …, 2011 - bloodjournal.hematologylibrary.org
... present study, we examined for the first time the in vivo consequences of constitutive expression
of a prothrombin active site ... mice and from mice with mutations influencing thrombin generation
(eg, TF, fV, or fX deficiencies) or thrombin substrates (eg, PAR-1 deficiency), in that ...
Cited by 2 - Related articles - All 3 versions

Approach to the treatment, characterization and diagnosis of an acquired auto‐antibody directed against factors prothrombin, factor X and factor IX: a case report and …

L Rochanda, GJ Del Zoppo, DI Feinstein… - …, 2011 - Wiley Online Library
... Factor V activity, fibrinogen and thrombin time assays were normal. ... A Western blot using an
anti-prothrombin murine monoclonal antibody and the same coagulation proteins found no
evidence of prothrombin contamina- tion in either the FX or FIX (data not shown). ...
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Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury

[HTML] from hematologylibrary.orgO Grottke, T Braunschweig… - …, 2011 - bloodjournal.hematologylibrary.org
... therefore, the optimal doses to include in investigation of the safety or efficacy of ... antithrombin
at a sufficient level to balance the thrombin-generating potential of prothrombin. ... PCC infusion
for trauma-induced coagulopathy to protect against excessive systemic thrombin levels. ...

Prothrombin complex concentrate and recombinant prothrombin alone or in combination with recombinant factor X and FVIIa in dilutional coagulopathy: a porcine …

T Mitterlechner, P Innerhofer, W Streif… - … of Thrombosis and …, 2011 - Wiley Online Library
... PCC group: 200 mg kg −1 fibrinogen concentrate and 35 IU kg −1 prothrombin complex
concentrate. ... 12], and, as a rule, more so than any other procoagulation factor or platelets [2 ... PCC
induced a stronger and much longer-lasting effect with regard to thrombin generation than ...
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Valproate-induced hyperammonemic coma in females with unrecognized partial ornithine transcarbamylase deficiency

RR McGoey, AH Conravey, J Wong… - Journal of Pediatric …, 2011 - IOS Press
... Correspondence: Robin R. McGoey, MD, Children's Hospital of New Orleans, 200 Henry Clay
Avenue, New Orleans, LA 70118, USA. Tel.: +1 504 896 9254; Fax: +1 504 896 3997; E-mail:
rmcgoe @lsuhsc.edu. ... n es, p ro tein av ersio n ; b ro th er an d tw o m atern al u n cles ...
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