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Effect of crystallisation conditions and feedstock morphology on the aerosolization performance of micronised salbutamol sulphate

MH Shariare, M de Matas… - International Journal of Pharmaceutics, 2011 - Elsevier
Salbutamol sulphate (SS) used in dry powder inhalers requires drug particles in the respirable
size range of 1–5 μm to achieve a suitable therapeutic effect. The aim of this study was therefore
to determine strategies for controlling drug substance characteristics pre and post- ...
Related articles - All 2 versions

Surface Modification of Micronized Drug Powders to Improve Aerosolization via Mechanical Dry Powder Coating

D Morton, Q Zhou, L Qu, I Larson… - 1st Electron. Conf. Pharm. …, 2011 - sciforum.org
Abstract: Objective: To improve the efficiency of aerosolisation in an air flow of two model micronized
drug powders by dry mechanical modification of particle surfaces. Method: Two model
drugs, micronized salbutamol sulphate (SS) and salmeterol xinaofoate (SX) powders ...
Cached - All 2 versions

Efficient drug delivery to lung epithelial lining fluid by aerosolization of ciprofloxacin incorporated into PEGylated liposomes for treatment of respiratory infections

S Chono, H Suzuki, K Togami… - Drug Development …, 2011 - informahealthcare.com
Purpose: The efficacy of aerosolization of ciprofloxacin (CPFX) incorporated into PEGylated liposomes
(PEGylated CPFX-liposomes) for the treatment of respiratory infections was evaluated.
Method: PEGylated CPFX-liposomes with 1,2-distearoyl-sn-glycero-3- ...
Related articles - All 3 versions

The Cell Membrane as a Major Site of Damage during Aerosolization of Escherichia coli

RJ Thomas, D Webber, R Hopkins… - Applied and …, 2011 - Am Soc Microbiol
This study aimed to provide data on the survival and site of damage of Escherichia coli cells
following aerosolization using two different techniques, nebulization and flow focusing. Four
metabolic stains were assessed for their ability to detect respiratory activities and ...
Cited by 1 - Related articles - All 3 versions

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

AK Madl, SV Teague, Y Qu, D Masiel… - Aerosol Science and …, 2012 - Taylor & Francis
Assessing the human health risks associated with engineered nanomaterials is challenging
because of the wide range of plausible exposure scenarios. While exposure to nanomaterials
may occur through a number of pathways, inhalation is likely one of the most significant ...

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