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Enhanced K+-channel mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE-/-mice

T Beleznai, H Takano… - Cardiovascular …, 2011 - cardiovascres.oxfordjournals.org
... decrease in pEC50 values (WT: 5.4±0.1, n=13; ApoE-/-: 6.2±0.1, n=12) without markedly ... was
the enhanced ability of TRAM-34 to decrease SLIGRL responses in arteries from WT compared
to ApoE-/- animals (Figure 2), suggesting an enhanced role for other K+ channels in ...
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Different expression of large-conductance calcium-activated K+ channels in human internal mammary and radial arteries

Y Shao, R Liew, B Guan… - Cardiovascular …, 2011 - cardiovascres.oxfordjournals.org
... channels, causing hyperpolarization of SMC membrane potential, thereby counteracting
vasoconstriction of graft arteries. ... 12 Membrane hyperpolarization secondary to these agents has
been demonstrated to occur via the activation of Ca 2+ -dependent potassium channels. ...
Cited by 1 - Related articles - All 5 versions

Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries

KM Gauthier, DH Goldman… - American Journal of …, 2011 - Am Physiological Soc
... channels. In rabbit arteries, 11(R),12(S),15(S)-THETA comigrated with biological
11,12,15-THETA, activated smooth muscle apamin-sensitive K + channels, and was
the only 11,12,15-THETA stereoisomer to cause relaxation (25). ...
Cited by 1 - Related articles - All 5 versions

[PDF] Endothelium-derived hyperpolarizing factor and vascular function.

[PDF] from hindawi.comMA Ozkor… - Cardiology research and …, 2011 - downloads.hindawi.com
... Thus, in human in- ternal mammary arteries, EDHF appears to be 11,12-EET, produced by an
EDHF synthase CYP450-2C and accounts for 40% of net endothelial relaxation by stimulating
large- conductance KCa + channels [6]. The role of EETs as potential EDHFs can be ...
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Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells

C Guibert, T Ducret… - … Receptor Potential Channels, 2011 - Springer
... Thus TRPV4 could form a functional Ca2+ signalling complex with RYR and BKCa channels
to induce hyperpolarization and arterial dilation. ... Indeed, TRPV4 is expressed both in endothelial
cells and SMC of mesenteric arteries. [33] 11,12 EET-induced hyperpolarization and ...
Cited by 1 - Related articles - All 3 versions

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