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Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections

LK Selin, MF Wlodarczyk, AR Kraft, S Nie… - …, 2011 - informahealthcare.com
Heterologous immunity is a common phenomenon present in all infections. Most of the time it
is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive
response it leads to a cascade of events that result in severe immunopathology. Infections ...
Cited by 1 - Related articles - All 3 versions

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

M Kool, G van Loo, W Waelput, S De Prijck… - Immunity, 2011 - Elsevier
Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin
editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of canonical
NF-κB activation. Tnfaip3 fl/fl Cd11c-cre + mice lacking A20 in DCs demonstrated ...
All 2 versions

CD8+ T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity

G Filaci, D Fenoglio… - Autoimmunity, 2011 - informahealthcare.com
Regulatory T lymphocytes (Treg) are fundamental for immune homeostasis since they contribute
to the induction of peripheral tolerance to autologous antigens and regulate effector immune
responses. Treg subsets are present within both the CD4+and the CD8 + T cell ...
Cited by 2 - Related articles - All 3 versions

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

[PDF] from umaryland.eduA Fasano - Physiological Reviews, 2011 - Am Physiological Soc
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited
to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more
attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, ...
Cited by 3 - Related articles - All 5 versions

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

MP Boldin, KD Taganov, DS Rao… - The Journal of …, 2011 - jem.rupress.org
Excessive or inappropriate activation of the immune system can be deleterious to the
organism, warranting multiple molecular mechanisms to control and properly terminate immune
responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged ...
Cited by 6 - Related articles - All 6 versions

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