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[PDF] from unlv.eduR Schofield, T Mika… - 2011 - digitalcommons.library.unlv.edu
Abstract Oxygen delivery rates must keep pace with the increased metabolic rate observed in
poikilothermic animals exposed to increased temperature if aerobic metabolism is to be
maintained. Physical failure of the oxygen delivery system to meet this increased demand ...
UE Martinez-Outschoorn, M Prisco… - Cell cycle ( …, 2011 - ncbi.nlm.nih.gov
Previously, we showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth
and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial
metabolism in breast cancer cells. To mechanistically understand how these metabolites ...
All 6 versions
CRH White, DA Doherty, JJ Henderson… - Obstetrical & …, 2011 - journals.lww.com
Current data suggest that umbilical arterial pH analysis is the most sensitive diagnostic indicator
of birth asphyxia. Essential criteria for the diagnosis of birth asphyxia include metabolic acidosis
(pH <7.0 and base deficit ≥12 mmol/L) in cord arterial blood. However, it is unclear ...
All 2 versions
A Suzuki, SA Stern, O Bozdagi, GW Huntley… - Cell, 2011 - Elsevier
We report that, in the rat hippocampus, learning leads to a significant increase in extracellular
lactate levels that derive from glycogen, an energy reserve selectively localized in
astrocytes. Astrocytic glycogen breakdown and lactate release are essential for long-term ...
Cited by 8 - Related articles - All 2 versions
D Whitaker-Menezes… - Cell cycle ( …, 2011 - ncbi.nlm.nih.gov
Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis,
and extrude lactate to "feed" adjacent cancer cells, which then drives mitochondrial ...
Cited by 1 - All 5 versions

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