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A Bredberg - Cancer, 2011 - Wiley Online Library
The focus of cancer research is on cancer-specific mutations, with most clinical trials involving
targeted drugs. Huge numbers of DNA lesions and tumor resistance events, in each of the >10
13 cells of a human individual, form a striking contrast to the low, and also very narrow, ...
Cited by 1 - Related articles - All 3 versions
S Podder… - Genomics, 2011 - Elsevier
Functional redundancy by gene duplication appears to be a common phenomenon in biological
system and hence understanding its underlying mechanism deserves much attention. Here,
we investigated the differences between functional compensation of monogenic and ...
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[PDF] from hindawi.comS Bevan… - 2011 - downloads.hindawi.com
... genetic risk in these conditions. To date, the GWAS technique has identified over
1212 new genetic loci predisposing to common polygenic disease (http://www.genome.
gov/gwastudies). Novel genetic associations with a range ...
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[PDF] from rcplondon.ac.ukP Henderson… - Clinical Medicine, 2011 - rcplondon.ac.uk
... Without a doubt the major breakthrough in not only IBD genetics but complex
polygenic disease as a whole was the discovery of NOD2/CARD15 in 1996. This
gene was discovered by the French paediatric gastroenterologist ...
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A Tonello… - Medical Hypotheses, 2011 - Elsevier
... Available online 13 November 2010. Abstract. Chronic obstructive pulmonary disease (COPD)
is a complex polygenic disease characterized by an abnormal inflammatory response to smoke,
and results in a progressive and debilitating condition with declining lung function. ...
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