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Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family

…, JM Jürgensmeier, M Shibuya, SR Wedge… - Molecular Cancer …, 2011 - AACR
Cediranib is a potent inhibitor of the VEGF receptor (VEGFR)-2 and VEGFR-3 tyrosine
kinases. This study assessed the activity of cediranib against the VEGFR-1 tyrosine kinase and
the platelet-derived growth factor receptor (PDGFR)-associated kinases c-Kit, PDGFR-α, ...
Cited by 1 - Related articles - All 3 versions

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

[PDF] from dbkgroup.orgM Brown, DC Wedge, R Goodacre, DB Kell… - …, 2011 - Oxford Univ Press
Results: Three workflows have been developed to allow for the rapid, automated and high-throughput
annotation and putative metabolite identification of electrospray LC-MS-derived metabolomic
datasets. The collection of workflows are defined as PUTMEDID_LCMS and perform ...
Cited by 4 - Related articles - All 7 versions

Phase I Clinical Trial Targeting CD20+ Non-Hodgkin'S Lymphoma (NHL) After Autologous Stem Cell Transplant With Anti-CD3× Anti-CD20 Bispecific Antibody Armed …

…, P Steel, L Ayash, M Abidi, J Wedge… - Biology of Blood and …, 2011 - bbmt.org
Biology of Blood and Marrow Transplantation, Volume 17, Issue 2, Pages S158-S159,
February 2011, Authors:LG Lum; A. Thakur; V. Ratanatharathorn; Z. Al-Kadhimi; E. Paul;
C. Skuba; P. Steel; L. Ayash; M. Abidi; J. Wedge; JP Uberti. ...
Cached - All 2 versions

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding

…, K McDaid, NR Smith, HM Weir, SR Wedge… - Molecular Cancer …, 2011 - AACR
Inhibition of VEGFR-2 signaling reduces angiogenesis and retards tumor growth. Current biotherapeutics
that inhibit VEGFR-2 signaling by either sequestering VEGF ligand or inhibiting VEGF binding
to VEGFR-2 may be compromised by high VEGF concentrations. Here we describe a ...
Cited by 2 - Related articles - All 3 versions

CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches

CE Eyers, C Lawless, DC Wedge, KW Lau… - Molecular & Cellular …, 2011 - ASBMB
Claire E. Eyers§2, Craig Lawless§1, David C. Wedge§1,3, King Wai Lau1, Simon J.
Gaskell2, Simon J. ... §These authors contributed equally to this work ... 1Michael Smith
Building, Faculty of Life Sciences,The University of Manchester, Manchester M13 9PT

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