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Blockade of Human Group X Secreted Phospholipase A2 (GX-sPLA2)-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a …

WR Henderson, RC Oslund, JG Bollinger… - Journal of Biological …, 2011 - ASBMB
Group X (GX) phospholipase A 2 , a member of a large group of secreted phospholipases A
2 (sPLA 2 s), has recently been demonstrated to play an important in vivo role in the release
of arachidonic acid and subsequent formation of eicosanoids. In a Th2 cytokine-driven ...

Relationship Between Airway Expression Of Secreted Phospholipase A2 Group X And Airway Hyperresponsiveness

TS Hallstrand, Y Lai, B Johnson… - American Journal of …, 2011 - Am Thoracic Soc
University of Washington, Seattle, WA, University of Washington, Seattle, University of
California, San Francisco, San Francisco, 1 2 3 ... University of California at Davis, Davis, CA
... Patients with exercise-induced bronchoconstriction (EIB) have increased levels of ...
All 3 versions

Integrin Avss8 On Dendritic Cells Regulates Airway Hyperresponsiveness Through Induction Of IL-17 In T Cells

X Huang, M Kudo, A Melton, X Ren… - American Journal of …, 2011 - Am Thoracic Soc
UCSF, Mission Bay, San Francisco, CA, University of California San Francisco, San
Francisco, CA, UCSF, San Francisco, UCSF Mission Bay, 1 2 ... Asthma is a complex chronic
inflammatory disease affecting millions of people worldwide. It is well accepted that Th2 ...
All 3 versions

Identification of Genetic Loci in Mice That Mediate Allergen-Induced Airway Hyperresponsiveness, Inflammation, and Serum IgG1

SNP Kelada, D Aylor, U Tavarez… - Proceedings of the …, 2011 - Am Thoracic Soc
We aim to identify interactions between genes and allergen ex- posure that are relevant to the
development of asthma in humans using a mouse model. To accomplish this, we first developed
a new mouse using house dust mite (HDM) allergen that recapitulates key features of ...
All 2 versions

Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice

C Perkins, N Yanase, G Smulian… - The Journal of …, 2011 - jem.rupress.org
Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma
models, and Stat6 activation by the common IL-4/IL-13R drives most mouse model
pathophysiology, including airway hyperresponsiveness (AHR). However, the precise ...
Cited by 2 - Related articles - All 3 versions

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