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Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

LS Steelman, RA Franklin, SL Abrams, W Chappell… - Leukemia, 2011 - nature.com
The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase
(ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated
signaling through the Ras/Raf/MEK/ERK pathway is often the result of genetic alterations ...
Cited by 1 - Related articles - All 3 versions

Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing

PA Greif, SH Eck, NP Konstandin, A Benet-Pagès… - Leukemia, 2011 - nature.com
Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next
generation technology, was used as a systematic approach to identify mutations in genomes
of various types of tumors including melanoma, lung and breast cancer, as well as acute ...
Cited by 1 - Related articles - All 4 versions

Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

R Ibbotson, A Athanasiadou, LA Sutton, Z Davis… - Leukemia, 2011 - nature.com
Trisomy 12 is a recurrent chromosomal aberration occurring in 10–20% of CLL that has been
associated with an intermediate risk. 1, 2 A small percentage, between 1.6 and 5%, of patients
with trisomy 12 also have trisomy 19 and may constitute a distinct subgroup. 3, 4, 5 This ...

Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia

X Zhang, M Reis, R Khoriaty, Y Li, P Ouillette… - Leukemia, 2011 - nature.com
The pathogenesis of chronic lymphocytic leukemia (CLL) remains incompletely understood.
1 Although acquired chromosomal aberrations have been demonstrated to influence CLL biology
and clinical behavior, it remains unclear what single gene defects other than p53 or ATM ...
All 3 versions

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

AM Martelli, C Evangelisti, W Chappell, SL Abrams… - Leukemia, 2011 - nature.com
It has become apparent that regulation of protein translation is an important determinant in controlling
cell growth and leukemic transformation. The phosphoinositide 3-kinase (PI3K)/phosphatase
and tensin homologue deleted on chromosome ten (PTEN)/Akt/mammalian target of ...
Cited by 1 - Related articles - All 3 versions

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