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Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

AJ Lawson, EA Walker, GG Lavery… - Proceedings of the …, 2011 - National Acad Sciences
In peripheral target tissues, levels of active glucocorticoid hormones are controlled by 11β-hydroxysteroid
dehydrogenase type 1 (11β-HSD1), a dimeric enzyme that catalyzes the reduction of cortisone
to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder ...
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… Cortisone and Dexamethasone in Human Serum Using Liquid Chromatography Tandem Mass Spectrometry and Assessment of Cortisol: Cortisone Ratios in Patients …

JA Ray, MM Kushnir, AL Rockwood… - Clinica Chimica Acta, 2011 - Elsevier
We developed a high sensitivity method for simultaneous measurement of cortisol, cortisone
and dexamethasone. Using this method, we compared concentrations of cortisol, cortisone and
their ratios in samples from intensive care unit (ICU) and non-ICU patients, and cortisol ...
All 2 versions

A semi-automated method for measuring salivary cortisol and cortisone by tandem mass spectrometry with sample extraction

L Owen, R Jones… - Endocrine Abstracts, 2011 - endocrine-abstracts.org
Introduction: There has been much interest recently in measuring both salivary cortisol and cortisone
due to the presence of 11β-hydroxysteroid dehydrogenase type 2 enzyme in the salivary
glands. This enzyme facilitates the conversion of cortisol to cortisone; hence the ...
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Simultaneous measurement of endogenous cortisol, cortisone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate in nails by use of UPLC–MS–MS

M Ben Khelil, M Tegethoff, G Meinlschmidt… - Analytical and …, 2011 - Springer
The method was validated for linearity, limits of detection and quantification, recovery, intra and
interassay precision, accuracy, and matrix effect. Samples from 10 adult women were analyzed
to provide proof-of-principle for the meth- od's applicability. Calibration curves were linear ...
Related articles - All 2 versions

Ear reconstruction using porous polyethylene implants: Effect of cortisone on edema reduction and healing process.

A Naumann, S Ehrmantraut, V Willnecker… - HNO, 2011 - ncbi.nlm.nih.gov
INTRODUCTION: Porous polyethylene implants are increasingly used for ear reconstruction.
Although the material used exhibits good biocompatibility, swelling and edema formation frequently
occur after implantation, which may be treated by prophylactic cortisone therapy. The aim ...

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