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[HTML] The Novel Immunosuppressive Protein Kinase C Inhibitor Sotrastaurin Has No Pro-Viral Effects on the Replication Cycle of Hepatitis B or C Virus

[HTML] from plos.orgT von Hahn, A Schulze, IC Wust, B Heidrich… - PloS one, 2011 - dx.plos.org
The pan-protein kinase C (PKC) inhibitor sotrastaurin (AEB071) is a novel immunosuppressant
currently in phase II trials for immunosuppression after solid organ transplantation. Besides
T-cell activation, PKC affects numerous cellular processes that are potentially important ...
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Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle

S Cohen, AK Marr, P Garcin… - Journal of virology, 2011 - Am Soc Microbiol
Parvoviruses are small, nonenveloped, single-stranded DNA viruses which replicate in the nucleus
of the host cell. We have previously found that early during infection the parvovirus minute virus
of mice (MVM) causes small, transient disruptions of the nuclear envelope (NE). We have ...
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[HTML] Rapid Titration of Measles and Other Viruses: Optimization with Determination of Replication Cycle Length

[HTML] from plos.orgB Grigorov, J Rabilloud, P Lawrence… - PloS one, 2011 - dx.plos.org
Measles virus (MV) is a member of the Paramyxoviridae family and an important human pathogen
causing strong immunosuppression in affected individuals and a considerable number of deaths
worldwide. Currently, measles is a re-emerging disease in developed countries. MV is ...
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Role of the CM2 Protein in the Influenza C Virus Replication Cycle

T Furukawa, Y Muraki, T Noda, E Takashita… - Journal of …, 2011 - Am Soc Microbiol
CM2 is the second membrane protein of influenza C virus. Although its biochemical
characteristics, coding strategy, and properties as an ion channel have been extensively
studied, the role(s) of CM2 in the virus replication cycle remains to be clarified. In order to ...
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[HTML] Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines

[HTML] from plos.orgA Frentzen, K Hüging, J Bitzegeio, M Friesland… - PLoS pathogens, 2011 - dx.plos.org
The barriers preventing viral transmission across species are only incompletely understood.
On one hand, narrow tropism reflects dependence of viruses on host cell factors and their
species-specific utilization. On the other hand, host cellular antiviral factors can preclude ...
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