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Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

RF Mullins, AD Dewald, LM Streb, K Wang… - Experimental Eye …, 2011 - Elsevier
Data from human genetics, histopathology, and animal models reveal a major role for the complement
system in the development of age-related macular degeneration (AMD). Genetic variations in
the complement factor H (CFH) gene are associated with an elevated risk of AMD. In this ...
All 2 versions

Sublytic Membrane-Attack-Complex (MAC) Activation Alters Regulated Rather than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal …

K Kunchithapautham… - Journal of Biological Chemistry, 2011 - ASBMB
Uncontrolled activation of the alternative complement pathway and secretion of vascular endothelial
growth factor (VEGF) are thought to be associated with age-related macular degeneration
(AMD). Previously, we have shown that in RPE monolayers, oxidative-stress reduced ...
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Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive VEGF secretion in retinal pigment epithelium monolayers

K Kunchithapautham… - Journal of Biological Chemistry, 2011 - ASBMB
Uncontrolled activation of the alternative com- plement pathway and secretion of vascular
en- dothelial growth factor (VEGF) are thought to be associated with age-related macular
degene- ration (AMD). Previously, we have shown that in RPE monolayers, ...
Related articles - All 2 versions

Relationship between complement membrane attack complex, CCL2 and VEGF in mouse model of laser-induced choroidal neovascularization

J Liu, P Jha, VV Lyzogubov, RG Tytarenko… - Journal of Biological …, 2011 - ASBMB
Present study investigated the interactions among complement membrane attack complex
(MAC), CCL2 and VEGF that occur in vivo during the development of choroidal neovascularization
(CNV). We first investigated the sequential expression of MAC, CCL2 and VEGF during ...
Related articles - All 2 versions

Relationship between Complement Membrane Attack Complex, Chemokine (CC Motif) Ligand 2 (CCL2) and Vascular Endothelial Growth Factor in Mouse Model of …

J Liu, P Jha, VV Lyzogubov, RG Tytarenko… - Journal of Biological …, 2011 - ASBMB
The present study investigated the interactions among the complement membrane attack complex
(MAC), CCL2, and VEGF that occur in vivo during the development of choroidal neovascularization
(CNV). We first investigated the sequential expression of MAC, CCL2, and VEGF during ...
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