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Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

J Brouwers, K Vermeire, C Grammen, D Schols… - Antiviral Research, 2011 - Elsevier
In the search for a successful HIV microbicide, many poorly water-soluble antiviral agents are
currently being investigated. Unfortunately, solubility and precipitation issues may limit intravaginal
concentrations and thus availability of these agents upon application of an aqueous gel ...
All 4 versions

In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells.

M Donia, D Maksimovic-Ivanic… - Cell cycle ( …, 2011 - ncbi.nlm.nih.gov
The NO-derivative of the HIV protease inhibitor saquinavir (Saq-NO) is a nontoxic variant of the
parental drug with enhanced anticancer activity on several cell lines. However, it is still unclear
whether the p53 status of the target cell might influence the sensitivity to Saq-NO. In this ...
All 6 versions

The Rainbow Cohort: 96 Week Follow-up of Saquinavir-containing Regimens in Previously Antiretroviral Therapy (ART)-naive and Pre-treated but Protease Inhibitor ( …

H Knechten, C Stephan, FA Mosthaf… - European journal of …, 2011 - ncbi.nlm.nih.gov
Objective: We have previously reported data from the German cohort of the multinational observational
prospective RAINBOW survey which assessed the tolerability and efficacy of ritonavir-boosted
saquinavir (SQV/r)-containing regimens over 48 weeks in routine clinical practice. This ...

Pharmacokinetic Interaction Study of Ritonavir-Boosted Saquinavir in Combination with Rifabutin in Healthy Subjects

X Zhang, S Fettner, E Zwanziger… - Antimicrobial Agents …, 2011 - Am Soc Microbiol
The effect of multiple doses of rifabutin (150 mg) on the pharmacokinetics of saquinavir-ritonavir
(1,000 mg of saquinavir and 100 mg of ritonavir [1,000/100 mg]) twice daily (BID) was assessed
in 25 healthy subjects. Rifabutin reduced the area under the plasma drug ...
Related articles - All 3 versions

The new and less toxic protease inhibitor Saquinavir-NO maintains anti-HIV. 1 properties in vitro indistinguishable from those of the parental compound Saquinavir

F Canducci, ER Ceresola, D Saita, Y Al-Abed… - Antiviral Research, 2011 - Elsevier
Although, the antiviral activity, tolerability and convenience of protease inhibitors have improved
significantly in recent years, toxicity-associated adverse events including diarrhea, lipid
alterations, disturbance of glucose homeostasis and liver enzyme elevations still remain a ...

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