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Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling

[HTML] from pnas.orgLD Jennings-Antipov, L Song… - Proceedings of the …, 2011 - National Acad Sciences
The protective antigen (PA) moiety of anthrax toxin forms oligomeric pores that translocate the
enzymatic moieties of the toxin—lethal factor (LF) and edema factor (EF)—across the endosomal
membrane of mammalian cells. Here we describe site-directed spin-labeling studies that ...
Cited by 2 - Related articles - All 5 versions

Quantum mechanical/molecular mechanical study of anthrax lethal factor catalysis

CR Smith, GK Smith, Z Yang, D Xu… - … Chemistry Accounts: Theory, …, 2011 - Springer
Abstract We report a hybrid quantum mechanical and molecular mechanical study of the
catalysis of anthrax lethal factor. The calculations suggest that the zinc peptidase uses the
same general base-general acid mechanism as in thermolysin and carboxypeptidase A, ...
Related articles - All 3 versions

Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax

AE Boyer, CP Quinn, CA Beesley… - Journal of Infectious …, 2011 - jid.oxfordjournals.org
Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part
of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected
from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), ...

Anthrax vaccination induced anti-lethal factor IgG: Fine specificity and neutralizing capacity

SR Crowe, L Garman, RJM Engler, AD Farris… - Vaccine, 2011 - Elsevier
The efficacy biomarker of the currently licensed anthrax vaccine (AVA) is based on quantity
and neutralizing capacity of anti-protective antigen (anti-PA) antibodies. However, animal
studies have demonstrated that antibodies to lethal factor (LF) can provide protection ...
Related articles - All 3 versions

Antidotes to anthrax lethal factor intoxication. Part 2: Structural modifications leading to improved in vivo efficacy

S Kim, GS Jiao, M Moayeri, D Crown… - Bioorganic & medicinal …, 2011 - Elsevier
New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified
potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-
side chain yielded analogs with improved efficacy in the rat lethal toxin model.
All 3 versions

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