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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

[HTML] from nih.govPM Krawczyk, B Eppink, J Essers… - Proceedings of the …, 2011 - National Acad Sciences
... To confirm that hyperthermia sensitizes cells to decreased PARP-1 activity, we analyzed HeLa
and ... In line with previous results, incubation at an elevated temperature resulted in diminished
survival of ... 3. A mild increase in temperature is toxic to cells lacking PARP-1 functionality ...
Cited by 1 - Related articles - All 4 versions

Mild Elevation of Body Temperature Reduces Tumor Interstitial Fluid Pressure and Hypoxia and Enhances Efficacy of Radiotherapy in Murine Tumor Models

A Sen, ML Capitano, JA Spernyak, JT Schueckler… - Cancer Research, 2011 - AACR
... to understand better the clinical benefits that can be achieved with various hyperthermia protocols.
In summary, in this study we show that mild warming of mice results in ... to stimulate many of the
same thermoregulatory responses as by increased ambient temperature (31, 50 ...
Related articles - All 3 versions

Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies

I Knippertz, MF Stein, J Dörrie… - … of Hyperthermia, 2011 - informahealthcare.com
... Ostberg and co-workers were the first to suggest that in the murine system mild thermal stress
in the form of fever-like whole body hyperthermia (WBH) might have the ability to enhance
Langerhans cell activation and migration out of the epidermis [37]. ...

Clinical outcomes of mild hyperthermia for locally advanced rectal cancer treated with preoperative radiochemotherapy

MK Kang, MS Kim… - … Journal of Hyperthermia, 2011 - informahealthcare.com
... Int J Hyperthermia 2010; 26: 211–223 Abstract. Shakil A, Osborn JL, Song CW.
Changes in oxygenation status and blood flow in a rat tumor model by mild
temperature hyperthermia. Int J Radiat Oncol Biol Phys 1999; 43: 859 ...

Counterpoint: Humans do not demonstrate selective brain cooling during hyperthermia

L Nybo… - Journal of Applied Physiology, 2011 - Am Physiological Soc
... 18.↵: Nybo L,; Secher NH,; Nielsen B. . Inadequate heat release from the human brain during
prolonged exercise with hyperthermia. J Physiol 545: 697–704, 2002. ... monitoring of brain
temperature during mild hypothermia. Magn Reson Imaging 27: 923–932, 2009. ...
Cited by 13 - Related articles - All 2 versions

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