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CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier
We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation
of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF
activity and expression of Wnt targets. This is coincident with decreased phosphorylation ...
Cited by 3 - Related articles - All 3 versions

Mesangial Cell Integrin [alpha] v [beta] 8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-[beta] and Regulating PECAM-1

S Khan, S Lakhe-Reddy, JH McCarty… - The American Journal of …, 2011 - Elsevier
Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin
αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming
growth factor-β (TGF-β). Kidney αvβ8 localizes to mesangial cells, which appose ...
Cited by 1 - Related articles - All 4 versions

TNF receptor subtype 2 induction by viral dsRNA involves IP-10 and TNF-α in glomerular mesangial inflammation

F Krötz - American Journal of Physiology-Renal Physiology, 2011 - Am Physiological Soc
Toll-like receptor subtype 3 (TLR3) is a unique member of the TLR family of innate immune
receptors. In contrast to most TLRs, which are can be activated by either bacterial, fungal, or
unknown stimuli, TLR3 is the only TLR subtype that can be activated by double-stranded ...
Related articles - All 3 versions

Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop

MS Simonson… - Journal of Biological Chemistry, 2011 - ASBMB
Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of collagen
accumulation, extracellular matrix remodeling, and renal and cardiac fibrosis in diabetes.
However, the mechanism by which ET-1 promotes collagen accumulation remains ...
Related articles - All 3 versions

Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells

I Loeffler, U Hopfer, D Koczan… - Journal of the American …, 2011 - Am Soc Nephrol
Mesangial cells in diabetic mice and human kidneys with diabetic nephropathy exhibit increased
type VIII collagen, a nonfibrillar protein that exists as a heterodimer composed of α1(VIII) and
α2(VIII), encoded by Col8a1 and Col8a2, respectively. Because TGF-β1 promotes the ...
All 4 versions

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