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[CITATION] Biological Mechanisms of Focal Glomerulosclerosis: A Major Cause of Acquired and Inherited Renal Disease

M Pollak - Annual Review of Medicine, 2011 - … Reviews 4139 El Camino Way, PO …

… System Activation, Oxidative Stress, Inflammation, and Impaired Nuclear Factor-Erythroid-2-Related Factor 2 Activity in the Progression of Focal Glomerulosclerosis

HJ Kim, T Sato, B Rodríguez-Iturbe… - Journal of Pharmacology …, 2011 - ASPET
The Imai rat is a model of spontaneous focal glomerulosclerosis, which leads to heavy
proteinuria, hyperlipidemia, hypertension, and progressive renal failure. Treatment with AT1
blockers (ARBs) ameliorates proteinuria, hyperlipidemia, and nephropathy in this model. ...
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Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

C Wei, S El Hindi, J Li, A Fornoni, N Goes… - Nature Medicine, 2011 - nature.com
Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease, compromising
both native and transplanted kidneys. Treatment is limited because of a complex
pathogenesis, including unknown serum factors. Here we report that serum soluble ...
Cited by 1

Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis

B Smeets, C Kuppe, EM Sicking… - Journal of the …, 2011 - Am Soc Nephrol
The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis
(FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells
(PECs) to determine whether PECs contribute to sclerosis. In three distinct models of ...
All 3 versions

Mutations in INF2 Are a Major Cause of Autosomal Dominant Focal Segmental Glomerulosclerosis

O Boyer, G Benoit, O Gribouval, F Nevo… - Journal of the …, 2011 - Am Soc Nephrol
The recent identification of mutations in the INF2 gene, which encodes a member of the formin
family of actin-regulating proteins, in cases of familial FSGS supports the importance of an intact
actin cytoskeleton in podocyte function. To determine better the prevalence of INF2 ...
Cited by 2 - Related articles - All 4 versions

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