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Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids

AP Sage, J Lu, E Atti, S Tetradis… - Journal of Bone and …, 2011 - Wiley Online Library
In hyperlipidemia, oxidized lipids accumulate in vascular tissues and trigger atherosclerosis.
Such lipids also deposit in bone tissues, where they may promote osteoporosis. We found previously
that oxidized lipids attenuate osteogenesis and that parathyroid hormone (PTH) bone ...
Cited by 3 - Related articles - All 3 versions

Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques

JE Feig, S Parathath, JX Rong, SL Mick… - Circulation, 2011 - Am Heart Assoc
Methods and Results— Reversa mice were fed an atherogenic diet for 16 weeks. Plasma lipid
levels were then reduced. Within 2 weeks, this reduction led to decreased monocyte-derived
(CD68 + ) cells in atherosclerotic plaques and was associated with emigration of these ...
Cited by 6 - Related articles - All 4 versions

Hyperlipidemia and cardiovascular disease: triglycerides–a revival of cardiovascular risk factor?

JR Nofer - Current Opinion in Lipidology, 2011 - journals.lww.com
The involvement of various lipid fractions in plasma in the pathogenesis of vascular diseases
has been a focus of intensive studies for many years. In this way, the causative role of LDLs in
the pathogenesis of atherosclerosis has been firmly established and therapeutic ...
Related articles - All 2 versions

Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects

DJ Rader - US Patent 7,932,268, 2011 - Google Patents
US 7,932,268 B2 Page 2 US PATENT DOCUMENTS 6,812,345 B2 11/2004 Robl et al. 6,846,836
B2 1/2005 Hamann et al. 6,858,622 B2 2/2005 Muller et al. 6,875,782 B2 4/2005 Cheng et
al. 6,884,812 B2 4/2005 Glombick et al. 6,916,809 B2 7/2005 Chen et al. 6,916,813 B2 7/ ...
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… Regulator, Inhibitor of Differentiation 3, Induces Glomerulonephritis in Apolipoprotein E-Deficient Mice:: A Model Linking Hyperlipidemia and Renal Disease

H Bagavant, Y Scindia, D Nackiewicz… - The American Journal of …, 2011 - Elsevier
The clinical association between hyperlipidemia and renal disease is well established, yet hyperlipidemia
as a cause for renal disease is rare. Apolipoprotein E–deficient (ApoE −/− ) mice develop hyperlipidemia
and are a model for atherosclerosis. Introducing deficiency of inhibitor of differentiation 3 ( ...
Related articles - All 3 versions

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