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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

I Varela, P Tarpey, K Raine, D Huang, CK Ong… - Nature, 2011 - nature.com
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene
in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale screen
of ~3,500 genes by PCR-based exon re-sequencing identified several new cancer genes ...
Cited by 17 - Related articles - All 8 versions

Carminomycin I Is an Apoptosis Inducer That Targets the Golgi Complex in Clear Cell Renal Carcinoma Cells

GM Woldemichael, TJ Turbyville, WM Linehan… - Cancer research, 2011 - AACR
Clear cell renal cell carcinoma (CCRCC) evolves due to mutations in the Von Hippel–Lindau
(VHL) tumor suppressor gene. Although the loss of VHL enables survival and proliferation of
CCRCC cells, it is also expected to introduce vulnerabilities that may be exploited for ...
Related articles - All 3 versions

Morphologic Features of Uterine Leiomyomas Associated With Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome: A Case Report

K Garg, SK Tickoo, RA Soslow… - The American Journal of …, 2011 - journals.lww.com
Patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome are prone
to develop smooth muscle tumors of the uterus and skin and also renal carcinomas. The morphologic
features of renal tumors that arise in the setting of HLRCC are well described, the ...

Many facets of chromosome 3p cytogenetic findings in clear cell renal carcinoma: the need for agreement in assessment FISH analysis to avoid diagnostic errors.

M Brunelli, M Fiorentino, S Gobbo… - Histology and …, 2011 - ncbi.nlm.nih.gov
Abnormalities of the locus chromosome 3p and the entire chromosome 3 are involved in the
cancerogenesis of clear cell renal carcinoma and may be detected by interphase fluorescence
in situ hybridization (interphase FISH). We observed a variable detection rate of ...

Importance of brain‑type fatty acid binding protein for cell-biological processes in human renal carcinoma cells.

A Tölle, H Krause, K Miller, K Jung… - Oncology reports, 2011 - ncbi.nlm.nih.gov
The molecular mechanisms underlying renal cell carcinoma (RCC) development and progression
are still not completely understood. The importance of fatty acid binding proteins (FABP) for the
progression of carcinomas has been shown for several tumors. However, the importance ...
Cited by 1

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