Molecular Biology and Evolution publishes research at the interface of molecular (including genomics) and evolutionary biology. We consider manuscripts containing patterns, processes, and predictions at all levels of population, taxonomic, functional, and phenotypic organizations. In addition to fundamental discoveries of broader scope and impact, we are interested in publishing new and improved methods, resources, technologies, and theories that will significantly advance evolutionary research. We also publish balanced reviews of recent developments in genome evolution and forward-looking perspectives suggesting future directions in a field or application of molecular evolution.