F Xie, X Zhou, MB Genter, M Behr, J Gu… - Drug Metabolism and …, 2011 - ASPET ... We showed that the loss of CYP2A5 expression did not alter systemicclearance of MMZ (at 50 mg/kg, ip); but it did significantly decrease the rates of MMZ metabolism in the OM, whereas FMO expression in the OM was not reduced. ... Related articles - All 3 versions
H de Jonge, H de Loor, K Verbeke… - Clinical Pharmacology …, 2011 - nature.com ... 4,5 The oral bioavailability and systemicclearance of these drugs are controlled mainly by the cytochrome P450 isoenzymes CYP3A4 and 3A5 and the drug transporter P-glycoprotein, which are expressed in enterocytes (affecting oral bioavailability) and hepatocytes (affecting ...
N Hu, S Xie, L Liu, X Wang, X Pan, G Chen… - Drug Metabolism and …, 2011 - ASPET ... To investigate whether higher oral exposure of verapamil in plasma of diabetic rats resulted from a decrease in systemicclearance, the pharmacokinetics of verapamil (Fig. 1C) were studied in diabetic and control rats after intravenous administration of verapamil (1 mg/kg). ... Cited by 1 - Related articles - All 4 versions
ZL Mao, RW Townsend, C Gao… - The Journal of …, 2011 - jcp.sagepub.com ... Median systemicclearance was 0.35 L/h/kg (or 28 L/h for an 80-kg patient), with intersub- ject variability estimated to be 40%. Clearance was sig- nificantly influenced by CYP2D6 genotype, age, serum creatinine concentration, and subject status (patient vs volunteer). ... Cited by 1 - Related articles - All 3 versions
SV Ball, JL Maxwell, MK Cruikshank… - …, 2011 - Br Soc Rheumatology Background: Transition from primary to secondary school can be worrying for all young people. The social aspects of the move have been found to be more important to young people than learning issues [1]. There have however been no studies in the rheumatology ... Related articles
F Xie, X Zhou, MB Genter, M Behr, J Gu… - Drug Metabolism and …, 2011 - ASPET ... We showed that the loss of CYP2A5 expression did not alter systemicclearance of MMZ (at 50 mg/kg, ip); but it did significantly decrease the rates of MMZ metabolism in the OM, whereas FMO expression in the OM was not reduced. ... Related articles - All 3 versions
H de Jonge, H de Loor, K Verbeke… - Clinical Pharmacology …, 2011 - nature.com ... 4,5 The oral bioavailability and systemicclearance of these drugs are controlled mainly by the cytochrome P450 isoenzymes CYP3A4 and 3A5 and the drug transporter P-glycoprotein, which are expressed in enterocytes (affecting oral bioavailability) and hepatocytes (affecting ...
N Hu, S Xie, L Liu, X Wang, X Pan, G Chen… - Drug Metabolism and …, 2011 - ASPET ... To investigate whether higher oral exposure of verapamil in plasma of diabetic rats resulted from a decrease in systemicclearance, the pharmacokinetics of verapamil (Fig. 1C) were studied in diabetic and control rats after intravenous administration of verapamil (1 mg/kg). ... Cited by 1 - Related articles - All 4 versions
ZL Mao, RW Townsend, C Gao… - The Journal of …, 2011 - jcp.sagepub.com ... Median systemicclearance was 0.35 L/h/kg (or 28 L/h for an 80-kg patient), with intersub- ject variability estimated to be 40%. Clearance was sig- nificantly influenced by CYP2D6 genotype, age, serum creatinine concentration, and subject status (patient vs volunteer). ... Cited by 1 - Related articles - All 3 versions
SV Ball, JL Maxwell, MK Cruikshank… - …, 2011 - Br Soc Rheumatology Background: Transition from primary to secondary school can be worrying for all young people. The social aspects of the move have been found to be more important to young people than learning issues [1]. There have however been no studies in the rheumatology ... Related articles
沪公网安备号：31010402006960 （网站）31010405000484 （蝌蝌APP）
安全保密
