A Lukic… - Prion, 2011 - landesbioscience.com Over the last decade remarkable advances in genotyping and sequencing technology have resulted in hundreds of novel gene associations with disease. These have typically involved high frequency alleles in common diseases and with the advent of next generation sequencing, disease ... Cached - All 4 versions
I Hafner-Bratkovič… - Prion, 2011 - ncbi.nlm.nih.gov Prion diseases are infectious conformational diseases. Despite the determination of many native prion protein (PrP) structures and in vitro production of infectious prions from recombinant PrP the structural background of PrP conversion remains the largest unsolved problem. The ... Cited by 2 - All 5 versions
JK Hines… - Prion, 2011 - austin.landesbioscience.com Yeast prions are heritable protein-based genetic elements which rely on molecular chaperone proteins for stable transmission to cell progeny. Within the past few years, five new prions have been validated and 18 additional putative prions identified in Saccharomyces cerevisiae. ... Cached - All 4 versions
J Ye… - Cell, 2011 - Elsevier The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al.(2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self- ...
KJ Verges, MH Smith, BH Toyama… - Nature Structural & …, 2011 - nature.com Prion proteins can adopt multiple infectious strain conformations. Here we investigate how the sequence of a prion protein affects its capacity to propagate specific conformations by exploiting our ability to create two distinct infectious conformations of the yeast [PSI + ] prion protein ... All 3 versions
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