JM Pruet, KR Jasheway, LA Manzano… - European journal of …, 2011 - ncbi.nlm.nih.gov Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great ...
A Porter, G Phillips, L Smith… - Toxicon, 2011 - Elsevier To protect against ricin intoxication, a genetically derived ricin A chain vaccine candidate (RVEc) was developed lacking the toxic N-glycosidase activity (Olson et al., 2004). The vaccine protects animals against an aerosolized ricin holotoxin (RT) challenge (Carra et al., ... All 2 versions
[PDF] from peerproject.euM Słomińska-Wojewódzka, I Sokołowska, S Wälchli… - 2011 - repository.peerproject.eu Page 1. A single point mutation in ricin A-chain increases toxin ... Running title: Intracellular transport of RTA (P250A) Key words: ricin A-chain, mutation P250A, endosomal-lysosomal degradation, EDEM1, retrotranslocation, endoplamic reticulum ... Related articles
[HTML] from warwick.ac.ukRA Spooner… - Current Topics in Microbiology and …, 2011 - wrap.warwick.ac.uk A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin. The free A chains are then dislocated, or retrotranslocated, across the ER membrane into the ... Cached
N Tyagi… - … of pharmaceutical sciences: official journal of …, 2011 - ncbi.nlm.nih.gov Ricin was encapsulated into various sterically stabilized liposomes having different density of folate on the surface and the cytotoxicity of ricin in these liposomes was examined in KB cells. The effect of monensin in free and various sterically stabilized liposomal forms ...
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