B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF activity and expression of Wnt targets. This is coincident with decreased phosphorylation ... Cited by 3 - Related articles - All 3 versions
A Lu, M Miao, TR Schoeb, A Agarwal… - The American Journal of …, 2011 - Elsevier Transforming growth factor-β (TGF-β) is key in the pathogenesis of diabetic nephropathy. Thrombospondin 1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-β activation in vitro and in diabetic animal models. Herein, we investigate the effect of blockade of TSP1- ... Related articles - All 4 versions
AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou… - Nature genetics, 2011 - nature.com We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. ... Cited by 4 - Related articles - All 5 versions
J Barratt… - Seminars in Nephrology, 2011 - Elsevier Since its first description more than 40 years ago, IgA nephropathy has become the most common pattern of primary glomerulonephritis identified in all areas of the world where renal biopsy is routinely performed. This review discusses advances in our understanding of the ...
G Viswanathan, H Tighiouart… - American Journal of …, 2011 - urologyaccess.org « PreviousNext »American Journal of Kidney Diseases Volume 57, Issue 4 , Page B102, April 2011. 341 Complications of Chronic Kidney Disease (CKD) by Level of Albuminuria and Proteinuria in the Irbesartan in Diabetic Nephropathy Trial (IDNT). Gautham Viswanathan*: ... Cached - All 2 versions
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