A Bredberg - Cancer, 2011 - Wiley Online Library The focus of cancer research is on cancer-specific mutations, with most clinical trials involving targeted drugs. Huge numbers of DNA lesions and tumor resistance events, in each of the >10 13 cells of a human individual, form a striking contrast to the low, and also very narrow, ... Cited by 1 - Related articles - All 3 versions
S Podder… - Genomics, 2011 - Elsevier Functional redundancy by gene duplication appears to be a common phenomenon in biological system and hence understanding its underlying mechanism deserves much attention. Here, we investigated the differences between functional compensation of monogenic and ... All 3 versions
[PDF] from hindawi.comS Bevan… - 2011 - downloads.hindawi.com ... genetic risk in these conditions. To date, the GWAS technique has identified over 1212 new genetic loci predisposing to common polygenicdisease (http://www.genome. gov/gwastudies). Novel genetic associations with a range ... View as HTML
[PDF] from rcplondon.ac.ukP Henderson… - Clinical Medicine, 2011 - rcplondon.ac.uk ... Without a doubt the major breakthrough in not only IBD genetics but complex polygenicdisease as a whole was the discovery of NOD2/CARD15 in 1996. This gene was discovered by the French paediatric gastroenterologist ... Related articles - View as HTML - All 4 versions
A Tonello… - Medical Hypotheses, 2011 - Elsevier ... Available online 13 November 2010. Abstract. Chronic obstructive pulmonary disease (COPD) is a complex polygenicdisease characterized by an abnormal inflammatory response to smoke, and results in a progressive and debilitating condition with declining lung function. ... Related articles - All 3 versions
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