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Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine

F Muller, J Konig, H Glaeser, I Schmidt… - Antimicrobial Agents …, 2011 - Am Soc Microbiol
The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular
secretion. The molecular mechanism of renal chloroquine secretion remains unknown. We hypothesized
that organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 ...
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Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 …

T Watanabe, H Kusuhara, T Watanabe… - Drug Metabolism and …, 2011 - ASPET
The present study investigated prediction of the overall renal tubular secretion and hepatic clearances
of anionic drugs based on in vitro transport studies. The saturable uptake of eight drugs, most
of which were OAT3 substrates (rosuvastatin, pravastatin, pitavastatin, valsartan, ...
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The anglerfish and uremic toxins

J Lowenstein - The FASEB Journal, 2011 - FASEB
... moved into fresh water, glomerular filtration evolved as the mechanism by which fish maintained
osmotic integrity and the tubules acquired transporters which reclaimed the filtered glucose and
other “valuable substances,” but these fish still relied on tubular secretion to dispose ...
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Suspicion of Drug-Drug Interaction between High-Dose Methotrexate and Proton Pump Inhibitors: A Case Report–Should the Practice Be Changed

F Ranchon, N Vantard, A Gouraud… - …, 2011 - content.karger.com
... toxicity has been demonstrated to be directly related to methotrexate plasma concentrations,
exposure time and the area under the curve [2]. Methotrexate is eliminated almost entirely in
unchanged form in the urine by passive glomerular filtration and active tubular secretion. ...
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Two unusual cases of hypothyroidism with renal dysfunction

ML Patel… - BMJ Case Reports, 2011 - casereports.bmj.com
... impaired renal function in hypothyroidism is multifactorial, the reduction in GFR due to the lower
cardiac output and renal blood flow is likely to be the predominant mechanism.1 It has also been
suggested that thyroxine may mediate tubular secretion of creatinine.2 Furthermore ...
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