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Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic

LB Hough, JW Nalwalk, J Yang, JL Conroy… - Pain, 2011 - Elsevier
The search for the mechanism of action of improgan (a nonopioid analgesic) led to the recent
discovery of CC12, a compound that blocks improgan antinociception. Because CC12 is a cytochrome
P450 inhibitor, and brain P450 mechanisms were recently shown to be required in opioid ...
Cited by 2 - Related articles - All 3 versions

Non-opioid analgesics

C Hebbes… - Anaesthesia & Intensive Care Medicine, 2011 - Elsevier
When it was first discovered in the 1500s, opium was heralded as the most potent analgesic.
The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which
it was held. The many adverse effects associated with its use (now attributed to ...
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SUSTAINED RELEASE MONOEXIMIC FORMULATIONS OF OPIOID AND NONOPIOID ANALGESICS

Y Qiu… - US Patent 20,110,166,171, 2011 - freepatentsonline.com
1. A sustained release monoeximic dosage form comprising: a single rate controlling
mechanism, a therapeutically effective amount of hydrocodone or an acceptable salt thereof
and a therapeutically effective amount of acetaminophen, wherein the amount of ...
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Nonopioid Analgesics in Pain Management

JM Berger… - Essentials of Pain Management, 2011 - Springer
Introduction Since patients rarely present with pure nociceptive pain (ie, pain caused by activity
in the neural pathways in response to damaging or potentially damaging stimuli) or neuropathic
pain (ie, pain initiated by a primary lesion or dysfunction in the nervous system), but rather ...
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Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment

ND Volkow… - JAMA: The Journal of the American …, 2011 - Am Med Assoc
... 5 This is likely to reflect more aggressive management of noncancer pain, facilitated in part by
the “regulatory” mandate from the Joint Commission to screen and manage pain, but also by
the lingering concerns regarding the safety of nonopioid analgesics, particularly those ...
Cited by 3 - Related articles - All 2 versions

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