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Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients

A Troisi, G Frazzetto, V Carola… - Social …, 2011 - Taylor & Francis
A large body of evidence links altered opioid signaling with changes in social behavior in
animals. However, few studies have attempted to determine whether similar links exist in
humans. Here we investigate whether a common polymorphism (A118G) in the mu-opioid ...
Cited by 2 - Related articles - All 5 versions

Heteromerization of the μ-and δ-Opioid Receptors Produces Ligand-Biased Antagonism and Alters μ-Receptor Trafficking

[HTML] from ukpmc.ac.ukL Milan-Lobo… - Journal of Pharmacology and Experimental …, 2011 - ASPET
Heteromerization of opioid receptors has been shown to alter opioid receptor pharmacology.
However, how receptor heteromerization affects the processes of endocytosis and postendocytic
sorting has not been closely examined. This question is of particular relevance for ...
Related articles - All 4 versions

Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers

[PDF] from yale.eduR Ray, K Ruparel, A Newberg… - Proceedings of the …, 2011 - National Acad Sciences
Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in
particular, in mediating the rewarding effects of drugs of abuse, including nicotine. A single nucleotide
polymorphism (SNP) in the human MOR gene (OPRM1 A118G) has been shown to alter ...
Related articles - All 4 versions

Opioid Receptor Trafficking

M Zastrow - The Opiate Receptors, 2011 - Springer
Membrane trafficking mechanisms play a fundamental role in controlling the number and subcellular
distribution of opioid receptors in target neurons. The membrane trafficking of opioid receptors
is remarkably specific and highly regulated, and there has been considerable progress in ...
Related articles - All 2 versions

Functional Selectivity at the μ-Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

KM Raehal, CL Schmid, CE Groer… - Pharmacological Reviews, 2011 - ASPET
Opioids are the most effective analgesic drugs for the management of moderate or severe
pain, yet their clinical use is often limited because of the onset of adverse side effects. Drugs
in this class produce most of their physiological effects through activation of the μ opioid ...

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