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Addition of 2-Deoxyglucose Enhances Growth Inhibition But Reverses Acidification in Colon Cancer Cells Treated with Phenformin

MA LEA, J CHACKO, S BOLIKAL… - Anticancer …, 2011 - ar.iiarjournals.org
A report that effects of butyrate on some cells may be mediated by activation of AMP-activated
protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce
differentiation and inhibit proliferation of colon cancer cells in a manner similar to ...
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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

[PDF] from unt.eduDF Egan, DB Shackelford, MM Mihaylova, S Gelino… - Science, 2011 - sciencemag.org
... S2), which is consistent with recent proteomic analyses (9). To examine ULK1 in vivo
phosphorylation sites, we used tandem mass spectrometry on epitope-tagged ULK1 isolated
from cells treated with or without the mitochondrial complex I inhibitor phenformin (10). ...
Cited by 31 - Related articles - All 7 versions

Liver uptake of Biguanides in rats

Y Sogame, A Kitamura, M Yabuki… - Biomedicine & …, 2011 - Elsevier
... The present study was designed to compare hepatic uptake of two biguanides, metformin and
phenformin, in vitro and in vivo. ... Keywords: Metformin; Phenformin; Hepatic uptake. Article Outline.
1. Introduction 2. Materials and methods 2.1. Compounds 2.2. ...
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Metabolic checkpoints in the growth of breast cancer cells

CAW Schneider - 2011 - gradworks.umi.com
... Two compounds, phenformin and rotenone, inhibit mitochondrial complex I. These
compounds selectively repressed insulin and Wnt signaling. AICAR, a direct AMPK
activator, inhibited responses induced by all growth factors. ...
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Metformin and Chronic Renal Impairment: A Story of Choices and Ugly Ducklings

JG Heaf… - Clinical Diabetes, 2011 - Am Diabetes Assoc
... Assertions 1 and 2: “Phenformin, a biguanide, causes LA.”. ... Phenformin, one of the earliest
biguanides, was rapidly discovered to cause an increased incidence of LA (129/100,000
patient-years), 1 a life-threatening condition with a mortality of 50%. ...

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