S Sreeja, TR Santhosh Kumar, BS Lakshmi… - The Journal of …, 2011 - Elsevier Selective estrogen receptor modulators (SERMs) are estrogen receptor (ER) ligands exhibiting tissue-specific agonistic or antagonistic biocharacter and are used in the hormonal therapy for estrogen-dependent breast cancers. Pomegranate fruit has been shown to exert ...
BS Katzenellenbogen, MK Bagchi… - 2011 - ideals.illinois.edu Estrogens are associated with the development and progression of breast cancer in addition to their role in normal reproductive physiology, and estrogen receptors (ER) mediate the actions of estrogen in target tissues by regulating the expression of numerous biologically ... Cached - All 2 versions
B Katzenellenbogen, A Nardulli, D Shapiro… - 2011 - ideals.illinois.edu Repressor of Estrogen Receptor Activity (REA) is an evolutionarily conserved protein with established roles in multiple, essential cellular processes including transcription, mitochondrial biogenesis and replicative senescence. Previous reports suggest that REA is a multifunctional ... Cached - All 2 versions
BS Katzenellenbogen, AS Belmont, DJ Shapiro… - 2011 - ideals.illinois.edu Among the first diagnostic tests performed upon finding a tumor in the breast is the determination of the expression of three proteins: the Estrogen Receptor α (ERα), the Progesterone Receptor (PR) and Heregulin 2 (HER2). The ER, though often considered responsible for driving ... Cached - All 2 versions
V Ribas, BG Drew, JA Le… - Proceedings of the …, 2011 - National Acad Sciences The metabolic syndrome reflects an aggregate of abnormalities including obesity, inflammation, hypertension, glucose intol- erance, dyslipidemia, and insulin resistance (1–3), and the clus- tering of these abnormalities is associated with the increased risk of ...