I Varela, P Tarpey, K Raine, D Huang, CK Ong… - Nature, 2011 - nature.com The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale screen of ~3,500 genes by PCR-based exon re-sequencing identified several new cancer genes ... Cited by 17 - Related articles - All 8 versions
GM Woldemichael, TJ Turbyville, WM Linehan… - Cancer research, 2011 - AACR Clear cell renal cell carcinoma (CCRCC) evolves due to mutations in the Von Hippel–Lindau (VHL) tumor suppressor gene. Although the loss of VHL enables survival and proliferation of CCRCC cells, it is also expected to introduce vulnerabilities that may be exploited for ... Related articles - All 3 versions
K Garg, SK Tickoo, RA Soslow… - The American Journal of …, 2011 - journals.lww.com Patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome are prone to develop smooth muscle tumors of the uterus and skin and also renal carcinomas. The morphologic features of renal tumors that arise in the setting of HLRCC are well described, the ...
M Brunelli, M Fiorentino, S Gobbo… - Histology and …, 2011 - ncbi.nlm.nih.gov Abnormalities of the locus chromosome 3p and the entire chromosome 3 are involved in the cancerogenesis of clear cell renal carcinoma and may be detected by interphase fluorescence in situ hybridization (interphase FISH). We observed a variable detection rate of ...
A Tölle, H Krause, K Miller, K Jung… - Oncology reports, 2011 - ncbi.nlm.nih.gov The molecular mechanisms underlying renal cell carcinoma (RCC) development and progression are still not completely understood. The importance of fatty acid binding proteins (FABP) for the progression of carcinomas has been shown for several tumors. However, the importance ... Cited by 1
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