LB Hough, JW Nalwalk, J Yang, JL Conroy… - Pain, 2011 - Elsevier The search for the mechanism of action of improgan (a nonopioid analgesic) led to the recent discovery of CC12, a compound that blocks improgan antinociception. Because CC12 is a cytochrome P450 inhibitor, and brain P450 mechanisms were recently shown to be required in opioid ... Cited by 2 - Related articles - All 3 versions
C Hebbes… - Anaesthesia & Intensive Care Medicine, 2011 - Elsevier When it was first discovered in the 1500s, opium was heralded as the most potent analgesic. The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which it was held. The many adverse effects associated with its use (now attributed to ... Related articles - All 3 versions
Y Qiu… - US Patent 20,110,166,171, 2011 - freepatentsonline.com 1. A sustained release monoeximic dosage form comprising: a single rate controlling mechanism, a therapeutically effective amount of hydrocodone or an acceptable salt thereof and a therapeutically effective amount of acetaminophen, wherein the amount of ... Cached
JM Berger… - Essentials of Pain Management, 2011 - Springer Introduction Since patients rarely present with pure nociceptive pain (ie, pain caused by activity in the neural pathways in response to damaging or potentially damaging stimuli) or neuropathic pain (ie, pain initiated by a primary lesion or dysfunction in the nervous system), but rather ... Related articles - All 2 versions
ND Volkow… - JAMA: The Journal of the American …, 2011 - Am Med Assoc ... 5 This is likely to reflect more aggressive management of noncancer pain, facilitated in part by the “regulatory” mandate from the Joint Commission to screen and manage pain, but also by the lingering concerns regarding the safety of nonopioidanalgesics, particularly those ... Cited by 3 - Related articles - All 2 versions