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Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.

SC Boyle, M Kim, MT Valerius… - Development ( …, 2011 - ncbi.nlm.nih.gov
The primary excretory organ in vertebrates is the kidney, which is responsible for blood
filtration, solute homeostasis and pH balance. These functions are carried out by specialized
epithelial cells organized into tubules called nephrons. Each of these cell types arise ...

Hypertension (HT) and low nephron number confirmed: Results of a coronial autopsy study

T Samuel, MD Hughson, WE Hoy… - … Meeting of the …, 2011 - espace.library.uq.edu.au
Background: Keller et al. described lower nephron numbers in 10 European adults with documented
hypertension (NEJM, 2003) and Brenner et al. proposed earlier that nephron underendowment
might be driving the hypertensive state (AJKD, 1995). We examined a larger series in the ...
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… insufficiency causes growth restriction and a nephron deficit but no hypertension in female offspring with adequate postnatal nutrition preventing the nephron deficit

ME Wlodek, AL Mibus, A Tan… - … Origins of Health & …, 2011 - espace.library.uq.edu.au
Wlodek, ME, Mibus, AL, Tan, A., Arena, D., Siebel, AL, Owens, JA and Moritz, KM (2007). Uteroplacental
insufficiency causes growth restriction and a nephron deficit but no hypertension in female offspring
with adequate postnatal nutrition preventing the nephron deficit. In: , Early Human ...
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Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

[PDF] from massgeneral.orgCQ Diep, D Ma, RC Deo, TM Holm, RW Naylor… - Nature, 2011 - nature.com
Loss of kidney function underlies many renal diseases 1 . Mammals can partly repair their nephrons
(the functional units of the kidney), but cannot form new ones 2, 3 . By contrast, fish add nephrons
throughout their lifespan and regenerate nephrons de novo after injury 4, 5 , providing a ...
Cited by 6 - Related articles - All 7 versions

Does nephron number matter in the development of kidney disease?

RN Douglas-Denton, BJ McNamara… - Ethnicity and …, 2011 - espace.library.uq.edu.au
The total number of nephrons in normal human kidneys varies over a 10-fold range. This variation
in total nephron number leads us to question whether low nephron number increases the risk
of renal disease in adulthood. This review considers the available evidence in humans ...
Cited by 4 - Related articles - Cached - All 2 versions

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