C Li, N Narkbunnam, RJ Samulski, A Asokan… - Gene Therapy, 2011 - nature.com Recombinant adeno-associated virus (rAAV) is a promising gene delivery vector and has recently been used in patients with hemophilia. One limitation of AAV application is that most humans have experienced wild-type AAV serotype 2 exposure, which frequently generates ... All 3 versions
G Gao, JM Wilson, L Vandenberghe… - EP Patent …, 2011 - freepatentsonline.com 1. An adeno-associated virus (AAV) comprising an AAV capsid of serotype hu.53 wherein the AAVhu.53 capsid has at least 95% identity with the sequence of amino acids 204 to 734 of SEQ ID NO: 186 and wherein the AAV further comprises a minigene having AAV inverted ... Cached
NM Kotchey, K Adachi, M Zahid, K Inagaki… - Molecular …, 2011 - nature.com Recombinant adeno-associated virus serotype 9 (rAAV9) vectors show robust in vivo transduction by a systemic approach. It has been proposed that rAAV9 has enhanced ability to cross the vascular endothelial barriers. However, the scientific basis of systemic administration of rAAV9 and ... All 3 versions
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