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EO Oloo, JA Yethon, MM Ochs, B Carpick… - Journal of Biological …, 2011 - ASBMB
Pneumolysin (PLY) is a cholesterol-binding, pore-forming protein toxin. It is an important virulence
factor of Streptococcus pneumoniae and a key vaccine target against pneumococcal
disease. We report a systematic structure-driven approach that solves a long-standing ...
Related articles - All 3 versions
RM Harvey, AD Ogunniyi, AY Chen… - Infection and …, 2011 - Am Soc Microbiol
Streptococcus pneumoniae is a leading cause of human diseases such as pneumonia,
bacteremia, meningitis, and otitis media. Pneumolysin (Ply) is an important virulence factor of
S. pneumoniae and a promising future vaccine target. However, the expansion of clones ...
S Molloy - Nature reviews. Microbiology, 2011 - ncbi.nlm.nih.gov
1. Nat Rev Microbiol. 2011 Jan;9(1):4. Pneumolysin: stimulating protection.
Molloy S. Comment on: PLoS Pathog. 2010;6(11):e1001191. PMID: 21204310
[PubMed - in process]. Publication Types: Comment.
Cited by 1 - All 2 versions
[PDF] from mdpi.comC Förtsch, S Hupp, J Ma, TJ Mitchell, E Maier… - Toxins, 2011 - mdpi.com
... Article Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-
Dependent Cytolysin Pneumolysin Still ... A major pathogenic factor of S. pneumoniae is the
cholesterol-dependent cytolysin, pneumolysin. It produces cell lysis at high concentrations ...
Cited by 1 - Related articles - All 2 versions
C Wippel, C Förtsch, S Hupp… - Journal of Infectious …, 2011 - jid.oxfordjournals.org
Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and
meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which
produces lytic pores at high concentrations. At low concentrations, it has other effects, ...

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