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[PDF] from harvard.eduDM Knipe - Replicating Vaccines, 2011 - Springer
Viral vaccines have traditionally been live, attenuated viruses, or inactivated virus/subunits.
Herpes simplex virus (HSV) vaccine candidates based on inactivated viruses or subunits
have not been effective thus far. In addition, attenuation of HSV to make a safe vaccine ...
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E Matsuo, CCP Celma, M Boyce… - Journal of …, 2011 - Am Soc Microbiol
The reverse genetics technology for bluetongue virus (BTV) has been used in combination with
complementing cell lines to recover defective BTV-1 mutants. To generate a potential disabled
infectious single cycle (DISC) vaccine strain, we used a reverse genetics system to ...
S Paolucci, R Gulminetti, R Maserati… - Current HIV …, 2011 - ingentaconnect.com
... In vivo selection of stop codons in the RT gene resulted in the accumulation of replication-
defective virus strains. ... In addition, the presence of replication defective virus variants might have
played a major role in the slow progression to disease in this patient. ...
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EE Zumbrun… - Replicating Vaccines, 2011 - Springer
Live attenuated vaccines represent the most successful approach for the prevention of
alphaherpesvirus infections, including varicella zoster virus, pseudorabies virus, and equine
herpes virus 1. It is reasonable to consider that live virus vaccines may also be effective for ...
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A Hiraguri, O Netsu, T Shimizu, T Uehara-Ichiki… - Archives of …, 2011 - Springer
Abstract The nonstructural protein pC6 encoded by rice grassy stunt virus is thought to
correspond functionally to the nonstructural protein pC4 of rice stripe virus, which can
support viral cell-to-cell movement. In a trans-complementation experiment with a ...
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