C Ligios, MG Cancedda, A Carta… - Journal of …, 2011 - Am Soc Microbiol Prions are misfolded proteins that are infectious and naturally transmitted, causing a fatal neurological disease in humans and animals. Prion shedding routes have been shown to be modified by inflammation in excretory organs, such as the kidney. Here, we show that sheep with ... Cited by 1 - Related articles - All 4 versions
KC Chen, M Xu, WJ Wedemeyer… - Biophysical journal, 2011 - ncbi.nlm.nih.gov The microsecond folding and unfolding kinetics of ovine prion proteins (ovPrP) were measured under various solution conditions. A fragment comprising residues 94-233 of the full-length ovPrP was studied for four variants with differing susceptibilities to classical scrapie in sheep. ...
GS Baron, AG Hughson, GJ Raymond… - Biochemistry, 2011 - ACS Publications Mammalian prion diseases involve conversion of normal prion protein, PrPC, to a pathological aggregated state (PrPres). The three-dimensional structure of PrPres is not known, but infrared (IR) spectroscopy has indicated high, strain-dependent β-sheet ... Cited by 2 - Related articles - All 2 versions
[HTML] from plos.orgS Iken, V Bachy, P Gourdain, A Lim, S Grégoire… - PLoS Pathogens, 2011 - dx.plos.org It is generally accepted that prion-specific antibodies can protect against mouse scrapie infection. However, passive antibody therapy is limited to the lymphoinvasion stage of the disease. Active immunization has been attempted but the results have been ... Cached
[HTML] from plos.orgO Andréoletti, L Orge, SL Benestad, V Beringue… - PLoS Pathogens, 2011 - dx.plos.org Following the bovine spongiform encephalopathy (BSE) crisis and the identification of its zoonotic properties, a sanitary policy has been implemented based on both eradication of transmissible spongiform encephalopathies (TSE) in food-producing animals and exclusion of known ... Cited by 1 - Related articles - Cached - All 4 versions